Sleep complaints are frequently reported by patients with Marfan and Ehlers Danlos syndrome (EDS). We examined the exact nature of sleep complaints in these patients. Periodic limb movements were much more reported in EDS (67%, p = 0.02) than in Marfan (27%, p = 0.25) compared to controls (8%). Pain and back complaints were highly presented in both groups, but most pronounced in EDS patients. Our study calls for greater attention to the presence of apnea, pain and periodic limb movements in these patients.(Verbraecken J, et.al. "Evaluation for sleep apnea in patients with EDS and Marfan: a questionnaire study". Clin Genet. 2001 Nov; 60 (5): 360-5).