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Classical Type: Diagnostic Criteria |
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The major diagnostic criteria for Classical Type EDS are
The minor diagnostic criteria for Classical Type EDS may include
- Smooth velvety skin
- molluscoid pseudo tumors
- Subcutaneous spheroids
- Complications of joint hypermobility (sprains, islocations/subluxations, pes planus, etc.)
- Muscle hypotonia, delayed gross motor development
- Easy bruising
- Manifestations of tissue extensibility and fragility (e.g., hiatal hernia, anal prolapse in childhood, cervical insufficiency)
- Surgical complications (post-operative hernias)
- Family history
Additional comments
- The skin manifestations range in severity; families with mild, moderate and severe expression have been described.
- Molluscoid pseudotumors are fleshy lesions associated with scars.
They are frequently found over pressure points (e.g., elbows).
- Spheroids are small subcutaneous spherical hard bodies, frequently
mobile and palpable on the forearms and shins. Spheroids may be
calcified and detectable radiologically.
- Recurrent joint subluxations are frequent in the shoulder, patella, and temporomandibular joints.
- Dyspareunia and sexual dysfunction are occasional complaints in the Classical and other types of EDS
- Fatigue is a frequent complaint.
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