High throughput analysis of extracellular matrix gene expression in connective tissue disorders
Richard Wenstrup, MD
Cincinnati Children's Hospital Research Foundation, Cincinnati, OH
"High throughput analysis of extracellular matrix gene expression in connective tissue disorders"
Dr. Richard Wenstrup, of Cincinnati Children's Hospital Medical Center,
will investigate the genetic causes of the various types of
Ehlers-Danlos syndrome (EDS). EDS is characterized by looseness of the
joints, which can result in painful joint dislocations and early-onset
arthritis. The various types of EDS can be differentiated, based on the
degree of joint looseness, skin changes and other specific findings.
Using the newest techniques, Dr. Wenstrup will screen many expressed
genes for a reduction in gene activity, a common cause of EDS, in order
to identify new causative genes for the disorder.