This is based on the individuals and how the defective connective tissue (collagen) presents. Those with EDS can have manifestations from mouth to anus, some of which are benign, and others can be lethal. Differential diagnoses should always be broad, and treatment must take into consideration not only the known complications of EDS but also the propensity of the paticular patient to manifest them. (Solomon.et.al Am J Gastro; 1996; 91, (11):2282-2288)