| Peter H. Byers, MD |
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Dr. Byers is a medical geneticist who has been on the
faculty at the University of Washington since 1977. He is the director of the Medical Genetics
Clinic at the University of Washington Medical Center and the Director of the
Medical Genetics Residency program. Hewas Editor of The American Journal of Human Genetics from 1993
through 1999, president of the American Board of Medical Genetics in 1997, and
president of the American Society of Human Genetics in 2005. He currently directs the Collagen Diagnostic
Laboratory, which does protein based and molecular genetic diagnostic studies
for a group of inherited connective tissue disorders, including forms of EDS.
He is recipient of several grants, including “Molecular Basis of Osteogenesis Imperfecta” and “Identification and Expression of Skin Specific Genes.” He is also working on a project called “Collagen Gene Targeting with AAV Vectors.” Dr. Peter Byers and his colleagues (William Kerwin, Ulrike Schwarze and Melanie Pepin) of the University of Washington School of Medicine (Seattle) are using high-resolution MRI to study major arteries in individuals with the vascular form of Ehlers-Danlos syndrome (EDS) in an effort to determine if certain types of drugs might reduce the risk of arterial rupture, the usual cause of premature death in affected individuals. The vascular form of EDS, EDS type IV, is a rare disorder that affects about 1/100,000 individuals and results from mutations in the type III collagen gene, COL3A1. Affected individuals die prematurely from arterial rupture. Currently there are no effective therapies. These investigators hope that study of the vascular wall by non-invasive techniques (MRI) will help to define new and effective treatments.
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