Can you help me to understand the bruising associated with EDS?
Subcutaneous bleeding are caused by collagen abnormalities in
the vessel wall. The high frequency of a bleeding tendency in Ehlers-Danlos
patients with normal tests for haemostasis (83%) supports the conventional
explanation for this clinical feature, that defects in the structural integrity
of skin and blood vessels lead to easy bruising. (Anstey A, Mayne K, Winter M,
Van de Pette J, Pope FM. "Platelet and coagulation studies in Ehlers-Danlos
syndrome." Br J Dermatol. 1991 Aug;125(2):155-63). Disorders of Vascular
Fragility - Reed E. Pyeritz MD, PhD Vol 29; (6): 2001
www.physportsmed.com/issues/2001/06_01/pyeritz.htm
Pepin M, Schwarze U, Superti-Furga A, Byers PH. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the
Vascular Type. N Engl J Med. 2000 Mar;
342(10):673-80. Erratum in: N Engl J Med 2001 Feb 1;344(5):392
www.physportsmed.com/issues/2001/06_01/pyeritz.htm
Pepin M, Schwarze U, Superti-Furga A, Byers PH. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the
Vascular Type. N Engl J Med. 2000 Mar;
342(10):673-80. Erratum in: N Engl J Med 2001 Feb 1;344(5):392