Extraarticular manifestations of the joint hypermobility syndrome may include the peripheral nervous system. The autonomic nervous system-related symptoms of the patients have a pathophysiological basis which suggests that dysautonomia is extraarticular manifestation in the joint hypermobility syndrome. (Gazit Y. Nahir AM,Grahame R, Jacob G. "Dysautonomia in joint hypermobility syndrome" Am J Med. 2003 Jul; 115 (1): 33-40. Comment in: Am J Med 2004 Jun 1; 116 (11):783; author reply 783-4).