The major diagnostic criteria for Kyphoscoliosis Type EDS are:

• Generalized joint laxity
• Severe muscle hypotonia at birth
• Scoliosis at birth, progressive
• Scleral fragility and rupture of the ocular globe

The presence of three major criteria in an infant is suggestive of the diagnosis and laboratory testing is warranted.

The minor diagnostic criteria are:

• Tissue fragility, including atrophic scars
• Easy bruising
• Arterial rupture
• Marfanoid habitus
• Microcornea
• Radiologically considerable osteopenia
• Family history, i.e., affected siblings